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doi: 10.1039/C6MB00600K 19 BoothNMyhillSMcLaren-HowardJ
In individuals with Trimethylaminuria, deficient trimethylamine oxidase activity in the liver hinders the oxidation of trimethylamine, leading to its buildup and subsequent release in bodily fluids [10]
When FMO3 is deficient or dysfunctional, TMA accumulates in the body, producing a characteristic fishy odor [9]
A randomized-controlled dietary intervention study performed by Wang and colleagues found that chronic red meat, but not white meat or non-meat ingestion, increases plasma and urine TMAO
