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Alternative TB-500 protocols for different goals Daily low-dose protocol For patients who prefer more frequent, lower-volume injections: Dose: 750 mcg 1 mg daily , subcutaneous Duration: 12 weeks continuous, then 4 weeks off Provides steady-state tissue levels without peaks and troughs of twice-weekly dosing Preferred by some patients with needle anxiety (smaller volume per injection) Body-weight-based TB-500 dosing Some practitioners calculate by weight for greater precision: Loading: 3060 mcg/kg per injection , twice weekly Maintenance: 30 mcg/kg once weekly For a 75 kg patient: loading = 2.254.5 mg per injection

Body composition data from the SURMOUNT-1 DXA substudy showed approximately 75% of weight lost came from fat mass and 25% from lean mass

Looking at this schedule, a single 30 mg vial covers weeks 1 through 8 completely (10 mg at 2.5 mg/week for 4 weeks, then 20 mg at 5 mg/week for 4 weeks, totaling 30 mg)

figures are shown for both 5 days/week and 3/week patterns