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Factors like genetics, age, overall health status, and existing medical conditions can significantly influence individual responses to glutathione modifications
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These include p62, also known as sequestosome 1 (SQSTM1), a ubiquitin-binding protein that targets protein aggregates for degradation via the autophagic pathway (26, 76, 83, 90)
In the nucleus, tAIF binds histones, inducing large-scale DNA fragmentation and chromatin condensationa caspase-independent process distinct from apoptotic DNA laddering [70]
