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CD44-deficient mice develop normally with changes in subpopulations and recirculation of lymphocyte subsets

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endogenous substances e.g., estrogens electrophiles e.g., arene oxides, unsaturated carbonyls, organic halides Free radical and other oxidative agents can deplete glutathione

Trillions of cells perform countless reactions every second, generating harmful byproducts that must be neutralized
