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According to the study: Excessive amounts of omega-6 polyunsaturated fatty acids (PUFA) and a very high omega-6/omega-3 ratio, as is found in todays Western diets, promote the pathogenesis of many diseases, including cardiovascular disease, cancer, and inflammatory and autoimmune diseases, whereas increased levels of omega-3 PUFA (a low omega-6/omega-3 ratio) exert suppressive effects

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In contrast to the AR, the structural basis of antagonism has been elucidated for other nuclear receptors, eg , from the structures of 4-hydroxyltamoxifen (4-OHT) bound to the ER 91 , RU-486 bound to the GR 91,92 and the antagonist GW6471 bound to PPAR- 93

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