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Further research is warranted to gain a better understanding the underlying mechanisms that drive these effects and to clarify the complex relationship between diet, TMAO, and IBD risk (163)

However, spermatogonia loss was higher than Sertoli and Leydig cell loss after busulfan exposure (39) and because the status of spermatic germ cells depends on Leydig and Sertoli cells function, apoptosis of these supporting cells can also endanger vitality of spermatic germ cells (46)

HC, healthy control

N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain