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doi: 10.1186/s40035-020-00228-9 336 WangLLiCChenXLiSShangH

466 However, mitochondria present unique challenges to proteostasis, including oxidative damage caused by reactive oxygen species (ROS) from the respiratory chain and constant remodeling, fusion, and fission events according to metabolic demands

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This means that only small concentrations get to the skin
