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Studies are revealing that in some cases checkpoint inhibitor MAb alone may induce clinical benefit, while in other cases, additional immune-mediating agents are necessary [140]

Woo et al, 1999) and by affecting the blood coagulation system (Constant et al, 1999

Different studies have shown that vitamin C acts as a multiorgan targeting agent and can play a role in epigenetic level, regulation of kinase activity, inhibition of epithelialtomesenchymal transition (EMT), immunoregulatory effect, increasing oxygen sensation, prooxidant activity, etc
