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Especially in the past half century, global warming has driven drier environment and higher water evaporation, as a result, leading to mucus thinning, epithelial compression and subsequent inflammation 289

doi: 10.1105/tpc.10.2.267

The applicant further stated that in clinical trials, SPEVIGO was associated with clinically significant improvements in patient-reported psoriasis symptoms, including fatigue, and significant decreases in markers of systemic inflammation

The intestinal microbiota is directly implicated in the generation of trimethylamine from dietary choline and its metabolite phosphatidylcholine, as well as from dietary betaine and carnitine