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10.1039/c9fo02032b 149 MehmoodA.ZhaoL.IshaqM.XinW.ZhaoL.WangC.et al (2020)

Journal of Alzheimer's Disease

A phase I/II multicenter study of single-agent foretinib as first-line therapy in patients with advanced hepatocellular carcinoma
DDIT3 promotes glycolysis by inhibiting TP53-induced glycolysis and apoptosis regulator (TIGAR) to generate ATP, while simultaneously facilitating the degradation of mitochondrial electron transport chain proteins [such as coenzyme Q9 homolog (COQ9) and cytochrome c oxidase subunit 4 (COX4)] via lon peptidase 1, mitochondrial (LONP1), thereby suppressing oxidative phosphorylation and reducing reactive oxygen species (ROS) production
