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If you eat a balanced diet, youre probably getting enough B12

Chronic fatigue syndrome in an ethnically diverse population: the influence of psychosocial adversity and physical inactivity

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In a systematic review and meta-analysis, depression was associated with significantly increased oxidative stress as measured by biomarkers of oxidative DNA damage (8-OHdG) and lipid peroxidation (F-isoprostanes) compared to non-depressed controls ( 3.5 Neurotrophic deficits and impaired hippocampal neurogenesis The diminishment of neurotrophic signaling, especially that related to brain-derived neurotrophic factor (BDNF), stands as a defining characteristic of depression