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A significant fraction of the heme moeity may be converted to metabolites other than bilirubin, such as mesobilifuscins, that are excreted in the bile/feces and urine ( Heterozygote females are often considered only as carriers, leading to under-diagnosis of G6PD deficiency as the underlying cause of severe hyperbilirubinemia

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The T allele of the + 874 A/T IFN- SNP, which causes higher IFN- production, is linked with the seriousness of hypothyroidism in patients with HT