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Mice fed a high-fat diet for 4 weeks showed a three- to fourfold increase in serum LPS, which is defined as metabolic endotoxemia
For people with life-threatening (fulminant) colitis (more than 10 stools per day with continuous blood, enlargement of the colon with fever, elevated heart rate, and laboratory tests indicating inflammation), hospitalization is required
These changes help counteract oxidative DNA lesions and misfolded protein accumulation
J Biol Chem 269: 1284612851 [PubMed] [Google Scholar] Boon E.M., van der Neut R., van de Wetering M., Clevers H., Pals S.T
