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B12 is crucial in brain function, nerve tissue health, and red blood cell production

Macrocyclic peptides as allosteric inhibitors of nicotinamide N -methyltransferase (NNMT)

Collectively, this study provides a solid foundation for future exploration into the impact of NNMTi-and diet-mediated changes to the gut microbiome in obese and lean populations, as well as future targets to investigate mechanistically with NNMTi treatment

Notably, NAM serves as the substrate for NAD + synthesis in the salvage pathway (Pissios, 2017)
