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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.George L.A., Cross R.K
[Google Scholar] 37
Herein, we report an l-buthionine-sulfoximine (BSO)-based hypertoxic self-assembled peptide derivative (NSBSO) with dual functions of GSH depletion and biosynthesis inhibition for selective tumor ferroptosis and pyroptosis
Animal studies also examined the AOD9604 mechanism of action at the molecular level, confirming that the peptide works through beta-3 adrenergic receptor activation and downstream stimulation of lipolysis
