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In MC-3 human mucoepidermoid carcinoma cells, PYC induced caspase-independent apoptosis and enhanced the stability of the pro-apoptotic Bak protein, suggesting its therapeutic relevance in salivary gland carcinomas ( Ex vivo studies further support the pro-apoptotic effects of PYC

10.1038/nm.4010 [DOI] [PMC free article] [PubMed] [Google Scholar] 27.Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, OHara SP, LaRusso NF, Miller JD, et al

We further uncovered GSH as a critical signaling molecule that relies on GLR3.3 to trigger long-distance propagation of calcium-based defense signaling events