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doi: 10.1016/j.neuroscience.2010.01.018
10.1096/fj.201700908R FASEB J
The crystal structures of inhibitor-complexed forms also indicate that Gly-473 to Thr-475 forms an oxyanion hole, which interacts with the oxyanion of the tetrahedral intermediate in the transition state
Variability in study protocols, glutamine dosages, and patient cohorts may contribute to the divergent findings, emphasizing the need for standardized approaches, and larger, well-controlled trials to elucidate the true impact of glutamine supplementation on mucositis and other treatment-related toxicities
