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First-line treatment is a macrolide antibiotic, which decreases transmission by eradicating the nasopharyngeal organism but does not alter the clinical course once paroxysms begin

Given the significant stiffness of the TME, anti-fibrosis emerges as a promising therapeutic approach for augmenting immunotherapy by targeting remodeled ECM components

It is to be noted that several others IC receptors can be expressed by effector lymphocytes (142, 319323) and further studies should show how much these additional IC are involved in the impairment of the MB recognition

In addition to its immunological functions, IL-2 is used in cancer therapy to boost anti-tumor immune responses 50