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Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly

doi: 10.1016/j.amsu.2021.102917

ADVERSE REACTIONS Adverse reactions include hyperkalemia, hyperphosphatemia, hypocalcemia, and hypomagnesemia
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ESF 921 Insect Cell Culture Medium, pVL dual vector and DH10Bac competent cells were purchased from Expression System
