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Abbreviations WGCNA: Weighted gene co-expression network analysis ROS: Reactive oxygen species GEO: Gene expression omnibus AUC: Area under the curve ROC: Receiver operating characteristic GSH: Glutathione GSSG: Oxidized glutathione lncRNAs: Long non-coding RNAs miRNAs: MicroRNAs ceRNA: Competing endogenous RNA DSigDB: Drug signatures database MSigDB: Molecular signatures database CEJ: Cementoenamel junction ABC: Alveolar bone crest DCA: Decision curve analysis PDB: Protein data bank IHC: Immunohistochemistry References Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, et al

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Some combinations trigger serotonergic excess at clinically standard doses due to individual receptor sensitivity variability

Limitations Several limitations occurred in this study