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2 AD In the early 20th century, German psychiatrist Alois Alzheimer, using silver-staining techniques on the brain tissue of a patient with cognitive decline, first described two hallmark lesions: extracellular senile plaques composed of -amyloid deposits and intraneuronal neurofibrillary tangles ( The traditional amyloid cascade hypothesis posits that A oligomers are the central pathogenic initiators in AD

Under conditions of metabolic stress, it migrates to the cell nucleus, where it activates a suite of genes governed by AMPK (AMP-activated protein kinase), the master cellular energy sensor

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One compound that has gained significant attention in regenerative and functional medicine is copper peptides , specifically GHK-Cu