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[DOI] [PMC free article] [PubMed] [Google Scholar] 457.Woolf, C
Long-term consequences include: Opioid physical dependence: Chronic mu-opioid receptor activation produces neuroadaptive tolerance, requiring escalating doses to maintain the same analgesic effect and producing withdrawal upon cessation
The Barrett esophagus can then be ablated more thoroughly and with a higher energy setting, without an increase in side effects or complications
