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Injections are a common method for those with moderate to severe B12 deficiency

According to the Centers for Medicare & Medicaid Services (CMS), Original Medicare (Parts A and B) covers vitamin B12 injections when theyre medically necessary when: You have a history of low blood levels of vitamin B12 or conditions that are caused by or cause low B12 levels such as certain autoimmune and gastrointestinal disorders

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This form of Vitamin B12 has been found effective in treating various conditions, including alcoholic neuropathy, pernicious anemia (caused by Vitamin B12 deficiency leading to inadequate red blood cell production), diabetic neuropathy (nerve damage due to high blood sugar levels), and multiple sclerosis (an immune system disorder affecting the brain)