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Primero, NAD+ funciona como coenzima redox directa: transporta electrones en la fosforilacin oxidativa (OXPHOS) y sirve de sustrato consumible para las PARP (reparacin de ADN) y las sirtuinas SIRT1-7, deacetilasas dependientes de NAD+ que regulan expresin gnica, biognesis mitocondrial y respuesta al estrs

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