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To overcome cellular impermeability to folate, vertebrates rely on multiple high-affinity transport systems: the reduced folate carrier (RFC), the proton-coupled folate transporter (PCFT), and folate receptors (FRs) [3,4,5,6]

At a dose of clomipramine hydrochloride 200 mg, subjects who had a single blood sample taken approximately 9 to 22 hours, (median 16 hours), after the dose had plasma concentrations of up to 605 ng/mL for CMI, 781 ng/mL for DMI, and 1386 ng/mL for both