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The study demonstrated elevated levels of pro-inflammatory cytokines, such as IL-1 and TNF-, in the brains of CKD mice, indicating that gut-derived signals play a central role in mediating neuroinflammation in CKD (Andrade-Oliveira et al., 2015)
Fowler, T
Cell, 142: 613624
Thus, to ensure that drugs are administered less often, effective and safe sustained release drugs from of biodegradable microparticles is required for pulmonary delivery
