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The Food and Drug Administration authorized the boosters Wednesday morning from both Pfizer-BioNTech and Moderna, and the director of the Centers for Disease Control and Prevention gave a thumbs up on the shots several hours later
Endocr Rev 16:6386 Korbonits M, Besser M 1996 Diagnosis of growth hormone deficiency in adults

No dose-escalation or maximum tolerated dose studies have been conducted, limiting understanding of safety at higher doses

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