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389,390,391 Zou et al

Activation of this pathway, thus on the one hand enhances mitochondrial biogenesis and function while on the other hand reduces ROS-dependent cellular stress (94)

These interventions aim to extend lifespan and reduce the impact and severity of age-related conditions, ensuring that additional years are characterized by vitality and wellbeing

As per the latest diagnostic criteria, MetS necessitates the presence of any three out of the following five conditions: elevated fasting glucose or type 2 diabetes (T2D), hypertriglyceridemia, lowered high-density lipoprotein (HDL) cholesterol levels, central obesity, or hypertension (Tilg et al., 2020)
