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Resistance to the antibodydrug conjugate T-DM1 is based in a reduction in lysosomal proteolytic activity

"Heterosexual Risk of HIV-1 Infection per Sexual Act: Systematic Review and Meta-Analysis of Observational Studies." Lancet Infect Dis 9.2 (2009): 118-29
If the vial was out for 8+ hours at room temperature (2025C), the conservative approach is to discard it and start a fresh vial

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