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Based on these and other findings, we have previously proposed that MDD may be associated with dysregulation of afferent warm signals from distal cutaneous sensors to the central nervous system, i.e., involving heat-defense mechanisms traveling along the spinoparabrachial pathway 32 , leading secondarily to decreases in sweating as assessed by measurement of skin conductance levels 12,33,34,35,36

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PMID: 29986520

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Not sterile

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In general, tryptophan metabolism is also impaired in IBD

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