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Metabolic reprogramming and redox factors involved in macrophage activation Metabolic reprogramming in macrophages Macrophages may be activated by cytokines, ROS, and PRR engagement by pathogen-associated molecular patterns, damage-associated molecular patterns, and commensal LPS leading to the activation of NF-B [42,43,44] and the PI3K/AKT signaling pathway [45, 46]

CD82 protects against glaucomatous axonal transport deficits via mTORC1 activation in mice

PMID: 19526854