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for instance, phosphorylation by Akt usually inactivates FoxO1a, FoxO3a, FoxO4, and FoxO6 proteins, whereas JNK activates FoxO4 and inactivates FoxO3a [143]
Dulhanty, A
109113,259,292,336343 In addition, prolonged hypoxia causes renal endothelium to produce pro-inflammatory adhesion molecules, cytokines, and chemokines that activate macrophages already resident within the kidney and also recruit additional inflammatory cells from the circulation
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