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In female mice, there were dose-related increases in the incidences of pituitary gland adenoma and carcinoma, and mammary gland adenocarcinoma at all doses tested (50 to 200 mg/kg/day or 1 to 5 times the MRHD based on mg/m2 body surface area)
Vitamin B12 deficiency in pregnancy can predispose women to pregnancy complications (such as preeclampsia or neural tube defects)

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Cai, H., Yi, W., Li, M., and et al
