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These toxicities can affect nearly any organ system but most commonly manifest as dermatologic toxicity, endocrinopathies, and severe autoimmune colitis , which requires prompt recognition and management with systemic corticosteroids

2014;9(5) doi: 10.1371/journal.pone.0094228.e94228 [DOI] [PMC free article] [PubMed] [Google Scholar] 163.Gmez-Sierra T., Molina-Jijn E., Tapia E., et al

Relying on one without the other introduces uncertainty

Based on its mechanism (synaptogenesis and HGF/c-Met pathway activation), Dihexa research is theoretically most relevant to: (1) Age-related cognitive decline (synaptic loss is a hallmark of brain aging)