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Exposure to MWCNTs resulted in cell membrane damage, increased formation of ROS and malonaldehyde, decreased intracellular glutathione levels, MMP collapse, and mitochondrial release of cyt c [144,145]

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As an example, Zhang et al found that the rate of leakage was unchanged in patients and that higher leakage volumes were observed mainly in the range of low leakage rates, in the order of noise ratio, suggesting that BBB leakage in these cSVD patients was subtle (521)