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doi: 10.1097/QAD.0000000000002248 502 DeeksSGOverbaughJPhillipsABuchbinderS

Dopamine oxidation, through the endogenous production of various neurotoxic metabolitessuch as dopamine quinones and thio-catecholaminestriggers a cascade of molecular events leading to cell death, with a high specificity for dopaminergic neurons in the substantia nigra
Misfolded syn, a presynaptic neuronal protein, forms soluble oligomers and insoluble fibrils that overwhelm cellular proteostasis mechanisms, leading to progressive intraneuronal accumulation [9, 10]

More time depends on the technical evaluation