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Potential side effects include: Injection site reactions, including redness, swelling, bruising, pain, or irritation Mild fluid retention (edema) Joint or muscle discomfort Headache, dizziness, or flushing Changes in glucose regulation, particularly in individuals with diabetes or prediabetes Itching, restlessness, drowsiness, nausea, or difficulty swallowing (3) Importantly, the occurrence of potential side effects does not predict an individual's overall response to therapy

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224 The lysine deacylase activity of SIRT4 is involved in the control of leucine metabolism and insulin secretion through regulating the acylation status of enzymes in these pathways
