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While Rimegepant, a CGRP receptor antagonist, has transformed migraine management, its efficacy is often limited by conventional oral delivery systems due to: Delayed onset of action Low solubility and variable bioavailability First-pass metabolism Difficulty in administration during nausea Thats where In-Situ Nasal Gel technology comes in offering a novel, patient-friendly approach to overcome these hurdles

[DOI] [PubMed] [Google Scholar] 135.Fan Z, Han Y, Ye Y, Liu C, Cai H