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Fistulas are a major Crohns disease complication, and this is one of the more clinically relevant preclinical findings

Some key responsibilities of NAD+ include: Fuelling mitochondrial energy production which gives power to all cellular processes Supporting DNA repair mechanisms Activating longevity-associated proteins, improving cell resistance to stress and metabolism Regulating circadian rhythms and communication between cells Just like glutathione, NAD+ levels decline with stress and age

Fratta Pasini et al., 2021)

BPC-157 has been associated with angiogenesis and growth-factor signaling, the pathways that build new blood supply and set up the repair environment, while TB-500 has been associated with actin regulation and cell migration, the machinery that moves repair cells into damaged tissue