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Despite promising results in basic experiments and animal models, which suggest that IGF-1 can enhance tendon cell proliferation, migration, collagen synthesis and markedly improve tendon mechanical properties and healing speed, clinical trial data supporting its efficacy in human tendon repair is still relatively scarce

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If you plan to discontinue tirzepatide, consider a gradual dose reduction over 8-12 weeks

Mutant polyprotein plasmids, in which the amino acid residues critical for protease (S835), ATPase (K899), and RNA-dependent RNA polymerase (D2379 and D2380) activities were replaced with alanine, were generated using a PrimeSTAR Max mutagenesis kit (Takara Bio Inc., Shiga, Japan)