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If severe, your provider might recommend staying at your current dose longer before increasing
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We found that removal of the R4 amino group was tolerated, as the corresponding analog 23 (R4 = H) exhibited an IC 50 value of 0.07 M and an EC 50 value of 2.3 M
doi:10.1016/j.pharmthera.2009.07.003 Purves D, Augustine GJ, Fitzpatrick D, et al
