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Description
When the soluble ionic form of the drug diffuses from the stagnant diffusion layer into the bulk of the solution whose pH is low, it is transformed into its free acid form having lesser aqueous solubility at the lower pH of the bulk solution
Hwang G, Marsh G, Gao L, Waugh R, Koo H
The interplay between Th1 and Th2 cells involves mutual regulation
Activation of downstream signaling: The binding of Dihexa to c-Met receptor activates downstream signaling pathways, including the mitogen-activated protein kinase (MAPK) pathway and the phosphoinositide 3-kinase (PI3K) pathway
