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References Schreiber AK, Nones CF, Reis RC, Chichorro JG, Cunha JM

Supporting evidence for the prefrontal hypodopaminergia came from PET (positron emission tomography) studies showing reduced cerebral blood flow in frontal cortex, which was directly correlated with low cerebrospinal fluid (CSF) DA metabolite levels in schizophrenia patients

The adenosine moiety binds down into a hydrophobic pocket, with the ribose phosphate groups pointing outside towards the GTP allosteric site