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In addition to serving as a substrate for protein synthesis, Trp is metabolized through the Kyn pathway via IDO1/tryptophan 2,3-dioxygenase (TDO) to generate metabolites such as Kyn, which can influence inflammatory transcription and immune tolerance through signaling axes such as the AhR ( In the immune microenvironment, Trp can enter the Kyn pathway through IDO1 or TDO, generating Kyn and its downstream metabolites

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Fa, I.M

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(66, 67) have reported that inhibiting glutamine metabolism in a murine model of TB has dual immunomodulatory and antibacterial activities

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[DOI] [PMC free article] [PubMed] [Google Scholar] 195.Zhang Y, Sun J, Zhu S, Xu T, Lu J, Han H, Zhou C, Yan J

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