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Two studies observed no change (Fuller and Hoppel, 1988

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2017 meta-analysis: A systematic review and meta-analysis of nine randomized controlled trials showed that ALCAR supplementation significantly decreased depressive symptoms compared to placebo (standardized mean difference 1.10, 95% CI 1.65 to 0.56), with effects comparable to established antidepressants like fluoxetine, particularly in older adults or those with treatment-resistant depression [5][30]

[5] [7] Common gastrointestinal side effects associated with fish oil include: Diarrhoea or loose stools Nausea and indigestion Abdominal discomfort or bloating Fishy aftertaste or belching Acid reflux symptoms For most people, these side effects are mild and transient, often resolving within a few days as the body adjusts to the supplement