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For example, O 2 triggers the intracellular p38 MAPK and JNK pathways, promoting apoptosis while also generating other ROS (such as H 2 O 2 ) to further amplify oxidative damage [218]
doi: 10.1038/s41419-022-04713-z
However, in cases of iron overload, excessive Fe 2+ is produced within the cell
[DOI] [PubMed] [Google Scholar] 197.Benyahia B., Huguet S., Declves X., Mokhtari K., Crinire E., Bernaudin J.F., Scherrmann J.M., Delattre J.Y
