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NO determination in colon tissue At the end of the experiment and at 15 min ligation time or at 15 min reperfusion time, we determined the NO levels in colon tissue samples using the Griess reaction (Griess Reagent System, Promega, United States)

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More importantly, the combination of Tepotinib and Larotrectinib showed better tumor inhibition (56% reduction) than treatment alone (20% reduction), but 1D228 showed more significant inhibition than the combination (Fig