melanotic macules wiki Lip macula - Hoogstra Smoker's melanosis - Wikipedia

[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Persaud SJ and Jones PM (2016) A Wake-up Call for Type 2 Diabetes

An immunohistochemical panel aimed at a risk stratification can encompass: - p16, which may disclose uneven immunoreactivity or clonal loss as an atypical feature ( - HMB45, which may be unevenly distributed, with loss of the gradient pattern seen in benign tumors ( - Cell cycle-related protein Ki67, which may show a high rate of expression and/or proliferative clusters in atypical lesions ( The traditional four-probe (targeting MYB , RREB , Cep6 , and CCND11 ) plus the anti- CDKN2A / Cep9 dual probe FISH examination may help refine the risk stratification of melanocytic tumors as recently proposed (86)

doi: 10.1002/1873-3468.12890

A., van Ommen, B