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Deciphering the crucial roles of transcriptional regulator GadR on gamma-aminobutyric acid production and acid resistance in Lactobacillus brevis

SLC39A14 is required for the development of hepatocellular iron overload in murine models of hereditary hemochromatosis

In phenylketonuria, altered amino acid metabolism leads to deficiencies in neurotransmitters like serotonin, dopamine, and norepinephrine, resulting in delayed sleep onset, prolonged latency, and excessive daytime sleepiness (Bruinenberg et al., 2017)

In brief, when TrkB and p75 NTR co-express in the same cells, p75 NTR enhances neurotrophin binding to TrkB, augmenting both ligand affinity and selectivity, hence, reinforcing the TrkB-mediated trophic response via up-regulation of PI3K/Akt and/or IRAK/NF-B signaling 3