large melanotic macule macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Labial Lentigo (labial melanotic macule)
Description
For example, urticaria pigmentosa is a condition that arises from mast cells and is occasionally associated with mast cell leukemia

The case also demonstrates gene aberrations not previously ascribed to MMNST, namely, BRAF copy number gain and KMT2C splice site, and GNAQ R183L missense mutations

Esta funcin detoxificadora es esencial para mantener la concentracin plasmtica de amonaco dentro de rangos compatibles con la funcin del sistema nervioso central

Skulachev M
